top of page

B12 Showdown: Cyanocobalamin vs. Methylcobalamin

An image of a syringe of vitamin B12 with the title "B12 Showdown: Cyanocobalamin vs. Methylcobalamin" overlaid on the image

Vitamin B12 is essential for nerve tissue health, brain function, and the production of red blood cells. It is available in several forms, with cyanocobalamin and methylcobalamin being the most commonly used in supplements. Understanding the differences between these forms can help you make an informed decision about which might be best for your health needs.

Pros and Cons of Cyanocobalamin


  • Stability and Shelf Life: Cyanocobalamin is a synthetic form of vitamin B12, which is more stable and has a longer shelf life than its natural counterparts. This makes it a popular choice for manufacturers and a cost-effective option for consumers.

  • Affordability: It is generally less expensive than methylcobalamin and is widely available in various supplement forms, including tablets, injections, and fortified foods.


  • Conversion Required: Cyanocobalamin needs to be converted into methylcobalamin or adenosylcobalamin in the body before it can be used effectively. This conversion process may be less efficient in some people, especially those with specific genetic mutations.

  • Contains Cyanide: Although the amount is clinically insignificant and not harmful to health, cyanocobalamin contains a cyanide molecule, which requires a small amount of energy from the body to detoxify.

Pros and Cons of Methylcobalamin


  • Bioactive Form: Methylcobalamin is the natural form of vitamin B12 used directly by the human body. It is readily absorbed and does not require conversion, which makes it ideal for people with absorption issues or genetic variations affecting B12 metabolism.

  • Supports Brain Health: Methylcobalamin is particularly effective in supporting neurological health and can reduce homocysteine levels, a common risk factor for cognitive decline and cardiovascular diseases.


  • Cost and Availability: It tends to be more expensive than cyanocobalamin and might not be as readily available in all regions or formulations.

  • Stability Issues: This form of B12 is sensitive to light and can degrade more easily, which may affect its effectiveness if not properly stored or handled.

Choosing the Right Form of B12

The choice between cyanocobalamin and methylcobalamin often depends on individual health needs and genetic factors. For most people, cyanocobalamin provides an effective and affordable way to meet their vitamin B12 needs. However, for those with specific health concerns, particularly related to the nervous system or methylation issues, methylcobalamin may be the better option.

Consulting with a healthcare provider is always recommended when deciding to take any supplement, especially if you have underlying health conditions or are pregnant. They can help determine the most suitable form of B12 based on your health profile and dietary needs. The providers at Regenerize are more than happy to help you make an informed decision.

Visit Regenerize to explore more about essential nutrients and how to optimize your health with the right supplements.

Medically Reviewed By Tawni Peterson, Family Nurse Practitioner.

7 views0 comments


Rated 0 out of 5 stars.
No ratings yet

Add a rating
bottom of page